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Semaglutide Improves Obesity-Induced Muscle Atrophy via Inhibition of UPS Degradation One other experimental study found that semaglutide inhibited UPS-mediated skeletal muscle proteolysis and degradation, diminishing the ubiquitin ligases atrogin-1 and MuRF-1, and promoted heat-shock factor-1-mediated myogenesis in murine myocytes [183]