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The experiments associated with the original observations that GLP-1 inhibits food intake and produces satiety in rats used intracerebroventricular injections for delivery of GLP-1, a common paradigm for assessment of anorectic peptides (7)

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Zepbound and Wegovy are FDA-approved for weight loss, Ozempic is approved for type 2 diabetes, has been used off-label for weight loss, if appropriate