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Moreover, combining GLP-1 with estrogen led to an activation of brain areas that were not affected by either of the substances alone given at doses matching those delivered by the conjugate (42), suggesting that when acting in the presence of estrogen GLP-1 has the potential to have a wider or different effect on the brain
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the amino group forms interaction with Glu205 and Glu206 (glutamic acids), whereas the cyano group was analyzed to bind with Arg125 via H-bond
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