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Bilchik emphasizes, “Careful consideration and ongoing investigation are essential to fully understand the impact of GLP-1 receptor agonists on colorectal cancer risk.” By balancing the benefits and risks, healthcare providers can optimize treatment strategies and improve patient outcomes in the complex landscape of metabolic health and cancer prevention.
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The reviewed data show that maternal exposure to GLP-1 agonists causes reduced embryonic-fetal survival, increases in major congenital anomalies, reduced fetal weight/growth, retardation of ossification, irregular ossification and skeletal variants in mice, rats and rabbits
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